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What should I discuss with my healthcare provider before taking fosamprenavir (Lexiva)?
You should not take this medication if you are allergic to fosamprenavir or a similar drug called amprenavir (Agenerase).
Life-threatening side effects may occur if you take fosamprenavir with: alfuzosin (Uroxatral), cisapride (Propulsid), delavirdine (Rescriptor), pimozide (Orap), rifampin (Rifadin, Rimactane, Rifater), lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin, Juvisync), midazolam (Versed), triazolam (Halcion), sildenafil (Revatio, for treating pulmonary arterial hypertension), St. John's wort, or an ergot medicine such as Ergomar, Cafergot, Wigraine, D.H.E. 45, Migranal, Methergine.
Fosamprenavir should not be taken together with ritonavir (Norvir) if you are also using a heart rhythm medication called flecainide (Tambocor) or propafenone (Rythmol). Ask your doctor about taking a different medication for your heart rhythm disorder.
To make sure you can safely take fosamprenavir, tell your doctor if you have any of these other conditions:
FDA pregnancy category C. It is not known whether fosamprenavir will harm an unborn baby. Tell your doctor if you are pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.
Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.
Taking fosamprenavir together with another HIV medicine called ritonavir (Norvir) and also using birth control pills can increase your risk of liver problems. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking fosamprenavir and ritonavir.
Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Fosamprenavir should not be given to an infant younger than 4 weeks (28 days) old.
How should I take fosamprenavir (Lexiva)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Fosamprenavir tablets can be taken with or without food.
Fosamprenavir liquid should be taken with food in children and without food in adults.
Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
If a child is taking this medication, tell your doctor if the child has any changes in weight. Fosamprenavir doses are based on weight in children.
Use fosamprenavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
To be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.
HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.
Store fosamprenavir tablets at room temperature away from moisture and heat.
You may store fosamprenavir liquid in the refrigerator but do not allow it to freeze.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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