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What should I discuss with my health care provider before I receive fosaprepitant (Emend for Injection)?

You should not use this medication if you are allergic to fosaprepitant, aprepitant (oral Emend).

The following drugs should not be used while you are receiving fosaprepitant:

• cisapride (Propulsid); or
• pimozide (Orap).

To make sure you can safely take fosaprepitant, tell your doctor if you have liver disease.

FDA pregnancy category B. Fosaprepitant is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while you are being treated with fosaprepitant.

Fosaprepitant can make birth control pills less effective, resulting in pregnancy. This effect can last for up to 28 days after your last dose of this medication. Talk to your doctor about the use of a non-hormonal back-up form of birth control (such as condoms, a diaphragm, or spermicides) during treatment with fosaprepitant and for at least 1 month after your treatment ends.

It is not known whether fosaprepitant passes into breast milk or if it could harm a nursing baby. Before you receive this medication, tell your doctor if you are breast-feeding a baby.

How is fosaprepitant given (Emend for Injection)?

Fosaprepitant is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Fosaprepitant must be given slowly, and the IV infusion can take at least 15 minutes to complete.

The first dose of fosaprepitant is usually given 30 minutes before your chemotherapy treatment begins.

You may also be given other medicines, including oral Emend (aprepitant capsules), for 3 or 4 days to further help prevent nausea and vomiting.

Fosaprepitant is not for long-term use.

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