What happens if I miss a dose (Cerebyx)?
Call your doctor for instructions if you miss a dose of fosphenytoin.
What happens if I overdose (Cerebyx)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of fosphenytoin can be fatal.
Overdose symptoms may include weakness, nausea, vomiting, feeling light-headed, chest pain, fast or slow heart rate, weak pulse, slow breathing (breathing may stop).
What should I avoid while using fosphenytoin (Cerebyx)?
Avoid drinking alcohol while you are receiving fosphenytoin. Alcohol use can increase your blood levels of fosphenytoin and may increase side effects. Daily alcohol use can decrease your blood levels of fosphenytoin, which can increase your risk of seizures.
What other drugs will affect fosphenytoin (Cerebyx)?
Drugs that can increase fosphenytoin levels in your blood include:
- amiodarone (Cordarone, Pacerone);
- disulfiram (Antabuse);
- fluorouracil (5FU, Adrucil);
- ethosuximide (Zarontin);
- isoniazid (for treating tuberculosis);
- methylphenidate (Ritalin, Concerta, Daytrana);
- tolbutamide (Orinase);
- birth control pills or hormone replacement therapy;
- chlorpromazine (Thorazine), prochlorperazine (Compazine, Compro), promethazine (Pentazine, Phenergan, Anergan, Antinaus), thioridazine (Mellaril), and other phenothiazines;
- phenobarbital (Solfoton) or other barbiturates;
- salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others;
- stomach acid reducers such as cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), or nizatidine (Axid);
- certain sedatives (such as Librium, Librax, Limbitrol, or Valium) or antidepressants such as fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax) or trazodone (Desyrel); or
- sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others).
Drugs that can make fosphenytoin less effective in controlling seizures include:
Other drugs that can interact with fosphenytoin include:
- a blood thinner such as warfarin (Coumadin, Jantoven);
- digoxin (digitalis, Lanoxin);
- furosemide (Lasix);
- steroid medications (prednisone and others);
- theophylline (Elixophyllin, Theo-Dur, Theo-Bid, Theolair, Uniphyl);
- valproic acid (Depakene) or divalproex sodium (Depakote);
- an antibiotic such as rifampin (Rimactane, Rifadin, Rifamate) or doxycycline (Doryx, Vibramycin, Adoxa, and others); or
- an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others.
This list is not complete and there are many other medicines that can interact with fosphenytoin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without your doctor's advice.
Where can I get more information?
Your pharmacist can provide more information about fosphenytoin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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