What happens if I miss a dose (Amaryl)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Use glimepiride regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
What happens if I overdose (Amaryl)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glimepiride overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, trouble speaking, blurred vision, nausea, fainting, and seizure (convulsions).
What should I avoid while taking glimepiride (Amaryl)?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Avoid exposure to sunlight or tanning beds. Glimepiride can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
What other drugs will affect glimepiride (Amaryl)?
Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:
- albuterol (Proventil, Ventolin);
- clonidine (Catapres);
- a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.
You may be more likely to have hypoglycemia (low blood sugar) if you take glimepiride with:
- clarithromycin (Biaxin);
- disopyramide (Norpace);
- exenatide (Byetta);
- fluoxetine (Prozac, Sarafem);
- probenecid (Benemid);
- an antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), norfloxacin (Noroxin), levofloxacin (Levaquin), and others;
- some nonsteroidal anti-inflammatory drugs (NSAIDs);
- aspirin or other salicylates (including Pepto-Bismol);
- a blood thinner (warfarin, Coumadin and others);
- a monoamine oxidase inhibitor (MAOI);
- sulfa drugs (Bactrim, Gantanol, Septra, and others); or
- other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).
You may be more likely to have hyperglycemia (high blood sugar) if you take glimepiride with:
- diuretics (water pills);
- steroids (prednisone and others);
- niacin (Advicor, Niaspan, Niacor, Niaspan, Simcor, Slo-Niacin, and others);
- phenothiazines (Compazine and others);
- thyroid medicine (Synthroid and others);
- birth control pills and other hormones;
- seizure medicines (Dilantin and others);
- diet pills; and
- medicines to treat asthma, colds or allergies.
Where can I get more information?
Your pharmacist can provide more information about glimepiride.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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