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glimepiride and rosiglitazone (cont.)

What should I discuss with my healthcare provider before taking glimepiride and rosiglitazone (Avandaryl)?

You should not use glimepiride and rosiglitazone if you have advanced heart failure if you are in a state of diabetic ketoacidosis (call your doctor for treatment).

To make sure you can safely take glimepiride and rosiglitazone, tell your doctor if you have any of these other conditions:

  • congestive heart failure, heart disease, a history of heart attack or stroke;
  • an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
  • liver disease or kidney disease;
  • adrenal or pituitary gland disorders; or
  • eye problems caused by diabetes.

Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glimepiride and rosiglitazone.

Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking glimepiride and rosiglitazone. Talk with your doctor if you are concerned about this possibility.

FDA pregnancy category C. Do not use glimepiride and rosiglitazone if you are pregnant. It is not known whether this medication will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Some women using glimepiride and rosiglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

It is not known whether glimepiride and rosiglitazone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using glimepiride and rosiglitazone.

How should I take glimepiride and rosiglitazone (Avandaryl)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take glimepiride and rosiglitazone with your first meal of the day.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating.

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.

Your doctor may want you to stop taking glimepiride and rosiglitazone for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

Ask your doctor how to adjust your dose if needed. Do not change your medication dose or schedule without your doctor's advice.

Store at room temperature, protected from moisture, heat, and light.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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