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Brand Names: Glucovance

Generic Name: glyburide and metformin (Pronunciation: GLYE bure ide and met FOR min)

• What is glyburide and metformin (Glucovance)?
• What are the possible side effects of glyburide and metformin (Glucovance)?
• What is the most important information I should know about glyburide and metformin (Glucovance)?
• What should I discuss with my healthcare provider before taking glyburide and metformin (Glucovance)?
• How should I take glyburide and metformin (Glucovance)?
• What happens if I miss a dose (Glucovance)?
• What happens if I overdose (Glucovance)?
• What should I avoid while taking glyburide and metformin (Glucovance)?
• What other drugs will affect glyburide and metformin (Glucovance)?
• Where can I get more information?

What is glyburide and metformin (Glucovance)?

Glyburide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Glyburide and metformin is used to treat type 2 diabetes (non-insulin dependent). This medication is not for treating type 1 diabetes.

Glyburide and metformin may also be used for purposes not listed in this medication guide.

Glucovance 1.25 mg-250 mg

oblong, yellow, imprinted with BMS, 6072

Glucovance 2.5 mg-500 mg

oblong, orange, imprinted with BMS, 6073

Glucovance 5 mg-500 mg

oblong, yellow, imprinted with BMS, 6074

GlyBURIDE-Metformin 1.25 mg-250 mg-GG

round, yellow, imprinted with cor 140

Glyburide-Metformin 1.25-250 mg-IVA

oblong, yellow, imprinted with LOGO 5710, 1.25/250

GlyBURIDE-Metformin 2.5 mg-500 mg-GG

round, orange, imprinted with cor 141

Glyburide-Metformin 2.5-500 mg-IVA

oblong, orange, imprinted with LOGO 5711, 2.5/500

GlyBURIDE-Metformin 5 mg-500 mg-GG

round, yellow, imprinted with cor 142

Glyburide-Metformin 5-500 mg-IVA

oval, yellow, imprinted with LOGO 5712, 5/500

What are the possible side effects of glyburide and metformin (Glucovance)?

This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

• pale or yellowed skin, dark colored urine, fever, confusion or weakness; or
• nausea, upper stomach pain, itching, loss of appetite, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• sneezing, runny nose, cough or other signs of a cold;
• headache, mild dizziness; or
• mild dizziness; or
• mild nausea or vomiting, diarrhea, upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about glyburide and metformin (Glucovance)?

You should not use this medication if you are allergic to glyburide or metformin, or if you have kidney disease or are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glyburide and metformin.

Before you take this medication, tell your doctor if you have liver or heart disease, a history of heart attack or stroke, or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Some people develop lactic acidosis while taking glyburide and metformin. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.

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