glyburide and metformin (cont.)
What happens if I miss a dose (Glucovance)?
Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Glucovance)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide and metformin overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
Overdose may also cause lactic acidosis. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
What should I avoid while taking glyburide and metformin (Glucovance)?
Avoid drinking alcohol. It can lower your blood sugar and may increase the risk of lactic acidosis while you are taking this medicine.
What other drugs will affect glyburide and metformin (Glucovance)?
Tell your doctor about all other medications you use, especially:
- cimetidine (Tagamet) or ranitidine (Zantac);
- morphine (MS Contin, Kadian, Oramorph);
- quinine (Qualaquin);
- an antibiotic such as ciprofloxacin (Cipro), trimethoprim (Proloprim, Primsol, Cotrim), or vancomycin (Vancocin, Lyphocin); or
- heart or blood pressure medicines such as amiloride (Midamor), digoxin (Lanoxin), furosemide (Lasix), nifedipine (Adalat, Procardia), procainamide (Pronestyl), quinidine (Quin-G), or triamterene (Dyrenium).
You may be more likely to have hyperglycemia (high blood sugar) if you take glyburide and metformin with other drugs that can raise blood sugar, such as:
- diuretics (water pills) or blood pressure medicine;
- steroids (prednisone and others);
- niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
- phenothiazines (Compazine and others);
- thyroid medicine (Synthroid and others);
- birth control pills and other hormones;
- seizure medicines (Dilantin and others);
- diet pills, medicines to treat asthma, colds or allergies; or
- heart or blood pressure medication such as diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others.
You may be more likely to have hypoglycemia (low blood sugar) if you take glyburide and metformin with:
- exenatide (Byetta);
- probenecid (Benemid).
- some nonsteroidal anti-inflammatory drugs (NSAIDs);
- aspirin or other salicylates (including Pepto-Bismol);
- a blood thinner (warfarin, Coumadin, and others);
- sulfa drugs Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others);
- a monoamine oxidase inhibitor (MAOI);
- beta-blockers (Toprol, Inderal, and others); or
- other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).
These lists are not complete and there are many other medicines that can increase or decrease the effects of glyburide and metformin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about glyburide and metformin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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