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Medications and Drugs

Brand Names: Drituss HD, Dynex HD, Entex HC, Hydro-Tuss XP, Hydrotussin HD, Nalex Expectorant, Poly-Tussin XP, Pseudatex HC, Su-Tuss HD Elixir, Tussgen Expectorant, Vanacon

Generic Name: guaifenesin, hydrocodone, and pseudoephedrine (Pronunciation: gwye FEN e sin, HYE droe KOE done, SOO doe ee FED rin)

What is guaifenesin, hydrocodone, and pseudoephedrine (Drituss HD, Dynex HD, Entex HC, Hydro-Tuss XP, Hydrotussin HD, Nalex Expectorant, Poly-Tussin XP, Pseudatex HC, Su-Tuss HD Elixir, Tussgen Expectorant, Vanacon)?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Hydrocodone is a narcotic. It is a pain reliever and a cough suppressant.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of guaifenesin, hydrocodone, and pseudoephedrine is used to treat cough and nasal congestion, and to reduce chest congestion caused by the common cold, infections, or allergies.

Guaifenesin, hydrocodone, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of guaifenesin, hydrocodone, and pseudoephedrine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

Less serious side effects may include:

  • dizziness or headache;
  • feeling excited or restless;
  • sleep problems (insomnia);
  • nausea, vomiting, or stomach upset;
  • mild loss of appetite;
  • warmth, tingling, or redness under your skin; or
  • skin rash or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about guaifenesin, hydrocodone, and pseudoephedrine?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Hydrocodone may be habit-forming and should be used only by the person this medicine was prescribed for. Keep the medication in a secure place where others cannot get to it.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Do not use any other over-the-counter cold, allergy, or cough medicine without first asking your doctor or pharmacist. Guaifenesin and pseudoephedrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain drug.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Identifier Tool

Need help identifying pills and medications?
Use the pill finder tool on RxList.



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