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Medications and Drugs

Brand Names: A-Tan 12X, Ryna-12X

Generic Name: guaifenesin, phenylephrine, and pyrilamine (Pronunciation: gwye FEN e sin, fen il EFF rin, and pir IL a meen)

What is guaifenesin, phenylephrine, and pyrilamine (A-Tan 12X, Ryna-12X)?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Pyrilamine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

The combination of guaifenesin, phenylephrine, and pyrilamine is used to treat runny or stuffy nose, sinus congestion, sneezing, watery eyes, and cough caused by allergies, the common cold, or the flu.

Guaifenesin, phenylephrine, and pyrilamine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of guaifenesin, phenylephrine, and pyrilamine (A-Tan 12X, Ryna-12X)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • blurred vision;
  • dry mouth;
  • dizziness, drowsiness, headache;
  • problems with memory or concentration;
  • ringing in your ears;
  • restless or excitability (especially in children);
  • warmth, tingling, or redness under your skin;
  • sleep problems (insomnia);
  • skin rash or itching; or
  • mild nausea, stomach pain, constipation.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about guaifenesin, phenylephrine, and pyrilamine (A-Tan 12X, Ryna-12X)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Tell your doctor if you regularly use other medicines that make you sleepy (such as pain medication, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by pyrilamine.

Avoid drinking alcohol while you are taking this medication. Alcohol can add to drowsiness caused by an antihistamine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains guaifenesin, phenylephrine, or pyrilamine.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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