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Medications and Drugs

Brand Names: Hydra-Zide

Generic Name: hydrochlorothiazide and hydralazine (Pronunciation: HYE droe KLOR oh THYE a zide and hye DRAL a zeen)

What is hydrochlorothiazide and hydralazine (Hydra-Zide)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Hydralazine is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.

The combination of hydrochlorothiazide and hydralazine is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and hydralazine is usually given after other blood pressure medications have been tried without successful treatment.

Hydrochlorothiazide and hydralazine may also be used for purposes not listed in this medication guide.

What are the possible side effects of hydrochlorothiazide and hydralazine (Hydra-Zide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • eye pain, vision problems;
  • dry mouth, thirst, nausea, vomiting;
  • feeling weak, drowsy, restless, or light-headed;
  • fast or uneven heart rate;
  • muscle pain or weakness;
  • confusion, unusual thoughts or behavior;
  • pale skin, easy bruising or bleeding;
  • painful or difficult urination;
  • urinating less than usual or not at all;
  • swelling in your face, stomach, hands, or feet;
  • numbness, burning, pain, or tingly feeling;
  • a red, blistering, peeling skin rash;
  • dark-colored urine, jaundice (yellowing of the skin or eyes); or
  • joint pain or swelling with fever, chest pain, weakness or tired feeling.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and hydralazine (Hydra-Zide)?

You should not use this medication if you are allergic to hydralazine (Apresoline) or hydrochlorothiazide, or if you have coronary artery disease, rheumatic heart disease affecting the mitral valve, or if you are unable to urinate.

Before using this medication, tell your doctor if you have liver disease, kidney disease, glaucoma, angina pectoris (chest pain), asthma or allergies, gout, lupus, diabetes, an allergy to sulfa drugs or penicillin, or if you have ever had a stroke.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and hydralazine.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

There are many other drugs that can interact with hydrochlorothiazide and hydralazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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