Medications and Drugs
Brand Names: Aldactazide
Generic Name: hydrochlorothiazide and spironolactone (Pronunciation: HYE dro KLOR oh THY a zide and spir ON oh LAK tone)
What is hydrochlorothiazide and spironolactone (Aldactazide)?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.
The combination of hydrochlorothiazide and spironolactone is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication also treats high blood pressure (hypertension).
Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide.
Aldactazide 25-25 mg
round, tan, imprinted with ALDACTAZIDE 25, SEARLE 1011
Aldactazide 50-50 mg
oblong, tan, imprinted with ALDACTAZIDE 50, SEARLE 1021
HCTZ-Spironolactone 25 mg-25 mg-GRE
round, beige, imprinted with 5014, G
HCTZ-Spironolactone 25 mg-25 mg-MYL
round, peach, imprinted with M 41
round, beige, imprinted with MP 40
What are the possible side effects of hydrochlorothiazide and spironolactone (Aldactazide)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have a serious side effect such as:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about hydrochlorothiazide and spironolactone (Aldactazide)?
You should not use this medication if you have kidney disease, urination problems, or high levels of potassium in your blood. Do not use potassium supplements while you are taking hydrochlorothiazide and spironolactone.
Before using this medication, tell your doctor if you have heart or liver disease, glaucoma, diabetes, a breathing disorder, gout, lupus, a pancreas disorder, an allergy to sulfa drugs or penicillin. Tell your doctor if you use a steroid or another blood pressure medicine.
Drinking alcohol can increase certain side effects of hydrochlorothiazide and spironolactone.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.
Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking hydrochlorothiazide and spironolactone.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Heart Health Resources
- Early Care for Your Premature Baby
- What to Eat When You Have Cancer
- When to Take More Pain Medication