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Medications and Drugs

Brand Names: Timolide 10-25

Generic Name: hydrochlorothiazide and timolol (Pronunciation: HYE droe klor oh THYE a zide and TYE moe lol)

What is hydrochlorothiazide and timolol (Timolide 10-25)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Timolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

The combination of hydrochlorothiazide and timolol is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and timolol may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hydrochlorothiazide and timolol (Timolide 10-25)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • sudden numbness or weakness on one side of the body, problems with vision or speech, chest pain, or pain in one or both legs;
  • numbness or tingly feeling in your hands or feet;
  • feeling weak, drowsy, restless, or light-headed;
  • nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
  • increased urination, leg discomfort, muscle pain or weakness or limp feeling;
  • urinating less than usual or not at all;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and timolol (Timolide 10-25)?

You should not use this medication if you have a history of asthma or severe chronic obstructive pulmonary disease (COPD), severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," an allergy to sulfa drugs, or if you are unable to urinate.

Before using this medication, tell your doctor if you have congestive heart failure, kidney or liver disease, cirrhosis, bronchospastic lung disease, gout, lupus, diabetes, a muscle disorder such as myasthenia gravis, a history of stroke, a thyroid disorder, or if you are allergic to sulfa drugs..

If you are diabetic, check your blood sugar carefully. Using timolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and timolol. Talk with your doctor before changing any doses.

Avoid drinking alcohol, which can lower your blood pressure and may add to the side effects of hydrochlorothiazide and timolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

There are many other medicines that can interact with hydrochlorothiazide and timolol. Tell your doctor about all the prescription and over-the-counter medications you use.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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