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Medications and Drugs

Brand Names: Lortuss HC, Nalex-DH

Generic Name: hydrocodone and phenylephrine (Pronunciation: high droe KOE dohn and fen ill EH frin)

What is hydrocodone and phenylephrine (Lortuss HC, Nalex-DH)?

Hydrocodone is a narcotic. It is a pain reliever and a cough suppressant.

Phenylephrine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in the body. Constriction of blood vessels in the sinuses and nose decreases congestion.

Hydrocodone and phenylephrine is used to treat cough and nasal congestion associated with the common cold, sinus infections, the flu, and bronchitis.

Hydrocodone and phenylephrine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of hydrocodone and phenylephrine (Lortuss HC, Nalex-DH)?

If you experience any of the following serious side effects, stop taking hydrocodone and phenylephrine and seek emergency medical attention or contact your doctor immediately:

  • a rare but serious allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
  • confusion, hallucinations, or unusual behavior.

Other, less serious side effects may be more likely to occur. Continue to take hydrocodone and phenylephrine and talk to your doctor if you experience

  • dizziness, drowsiness, or sleepiness;
  • restlessness or irritability;
  • blurred vision;
  • constipation;
  • dry mouth;
  • nausea, vomiting, or decreased appetite;
  • muscle twitches;
  • sweating;
  • itching; or
  • decreased urination.

Hydrocodone is habit forming. It is possible become physically and/or psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if hydrocodone and phenylephrine is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrocodone and phenylephrine (Lortuss HC, Nalex-DH)?

Use caution when driving, operating machinery, or performing other hazardous activities. Hydrocodone and phenylephrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking hydrocodone and phenylephrine.

Hydrocodone and phenylephrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other medicine without first talking to your doctor.

Hydrocodone is habit forming. It is possible become physically and/or psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if hydrocodone and phenylephrine is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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