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Medications and Drugs

Brand Names: Xyralid RC

Generic Name: hydrocortisone and lidocaine topical with psyllium (Pronunciation: HYE droe KORT i sone, LYE doe kane TOP ik al, SIL ee um)

What is hydrocortisone and lidocaine topical with psyllium (Xyralid RC)?

Hydrocortisone is a steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and itching.

Lidocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.

Psyllium is a type of soluble fiber used as a bulk-forming stool softener. Psyllium is not a laxative.

The combination of hydrocortisone and lidocaine topical (for the skin) is used to relieve itching, pain or other discomforts caused by conditions such as hemorrhoids or anal fissures (tiny tears in the tissues surrounding the anus). Psyllium is provided as a medication you take by mouth to help soften your stools, making them easier and less painful to pass while your rectal condition is being treated.

Hydrocortisone and lidocaine topical may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hydrocortisone and lidocaine topical with psyllium (Xyralid RC)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have severe irritation or burning of the treated area, or if you show signs of absorbing hydrocortisone topical through your skin, such as:

  • blurred vision, or seeing halos around lights;
  • mood changes;
  • sleep problems (insomnia);
  • weight gain, puffiness in your face; or
  • muscle weakness, feeling tired.

Less serious side effects may include:

  • mild stinging, burning, or redness where the medication is applied;
  • thinning of your skin;
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrocortisone and lidocaine topical with psyllium (Xyralid RC)?

You should not use this medication if you are allergic to hydrocortisone, lidocaine (or any other type of numbing medicine), or psyllium, or if you have severe liver disease, a fungal infection, smallpox, chickenpox, herpes, or tuberculosis.

Before using hydrocortisone and lidocaine topical with psyllium, tell your doctor if you have liver or kidney disease, a heart rhythm problem, congestive heart failure, stomach or intestinal conditions, diabetes, or any type of infection.

Do not take hydrocortisone rectal by mouth. It is for use only in your rectum.

Do not cover the treated rectal areas with a bandage, plastic pants or other covering unless your doctor has told you to. Covering the skin that is treated with hydrocortisone and lidocaine topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Your body may also absorb more of this medication if you use too much.

Contact your doctor if your condition does not improve or if it gets worse after using this medication.

Do not use this medication in a child without a doctor's advice. Children are more sensitive to the effects of hydrocortisone and lidocaine topical.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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