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What should I discuss with my health care provider before receiving hydroxocobalamin (Cyanokit, Hydroxocobalamin)?

If possible before you receive hydroxocobalamin, tell your caregivers if you have:

• high blood pressure;
• heart disease;
• congestive heart failure;
• liver disease;
• kidney disease (or if you are on dialysis); or
• if you have ever had a severe allergic reaction to hydroxocobalamin, Vitamin B12, or cyanocobalamin (Nascobal, Cobolin, Cyomin, and others).

FDA pregnancy category C. Tell your doctor if you are pregnant. It is not known whether hydroxocobalamin will harm an unborn baby. However, the benefits of treating cyanide poisoning may outweigh any risks posed by hydroxocobalamin, for both you and your baby.

It is not known whether hydroxocobalamin passes into breast milk or if it could harm a nursing baby. You should not breast-feed after you have been treated with hydroxocobalamin.

In an emergency situation, it may not be possible before you are treated with hydroxocobalamin to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How should I take hydroxocobalamin (Cyanokit, Hydroxocobalamin)?

Hydroxocobalamin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Hydroxocobalamin must be given slowly, and the IV infusion can take at least 15 minutes to complete.

Hydroxocobalamin is usually given only once. However, you may receive a second dose if needed.

Your breathing, blood pressure, oxygen levels, heart function, and other vital signs will be watched closely while you are receiving hydroxocobalamin.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you have recently received a hydroxocobalamin injection.

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