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What should I discuss with my healthcare provider before receiving hydroxyprogesterone (Makena, Prodrox)?

You should not receive this medication if you are allergic to hydroxyprogesterone or castor oil, or if you have:

• unusual vaginal bleeding that has not been checked by a doctor;
• liver disease or liver cancer;
• a hormone related cancer such as breast or uterine cancer;
• severe or uncontrolled high blood pressure;
• a history of jaundice caused by pregnancy; or
• a history of a stroke, blood clot, or circulation problems.

To make sure you can safely use hydroxyprogesterone, tell your doctor if you have any of these other conditions:

• eclampsia or preeclampsia of pregnancy;
• kidney disease;
• high blood pressure, heart disease;
• migraine headaches;
• a personal or family history of diabetes;
• asthma;
• seizures;
• depression; or
• fluid retention.

Hydroxyprogesterone passes into breast milk, but it is not known whether this could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is hydroxyprogesterone given (Makena, Prodrox)?

Hydroxyprogesterone is injected into a muscle. You will receive this injection in a clinic or doctor's office.

Hydroxyprogesterone is usually started during the 16th week of pregnancy and given once per week until the 37th week or until your baby is born. Follow your doctor's instructions.

Your doctor will need to check your progress on a regular basis while you are using this medication. Do not miss any scheduled appointments. Every woman should remain under the care of a doctor during pregnancy.

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