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ibritumomab (cont.)

What should I discuss with my healthcare provider before receiving ibritumomab (In-111 Zevalin, Y-90 Zevalin)?

You should not receive this medication if you are allergic to ibritumomab, or to radioactive chemicals or mouse proteins.

To make sure you can safely take ibritumomab, tell your doctor if you have any of these other conditions:

Some people receiving ibritumomab have developed "secondary" bone marrow or blood cell cancers such as leukemia. Talk with your doctor about your individual risk while receiving this medication.

Ibritumomab is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

FDA pregnancy category D. Do not use ibritumomab if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether ibritumomab passes into breast milk or if it could harm a nursing baby. Do not receive ibritumomab without telling your doctor if you are breast-feeding a baby.

How is ibritumomab given (In-111 Zevalin, Y-90 Zevalin)?

Ibritumomab is used in combination with rituximab (Rituxan) and a radioactive chemical. Ibritumomab is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Ibritumomab is usually given every 7 to 9 days. Follow your doctor's instructions.

Ibritumomab can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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