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Medications and Drugs

Brand Names: Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Children's Ibuprofen Cold Relief, Dristan Sinus, Motrin Childrens Cold

Generic Name: ibuprofen and pseudoephedrine (Pronunciation: EYE bue pro fen and SOO doe ee FED rin)

What is ibuprofen and pseudoephedrine (Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Children's Ibuprofen Cold Relief, Dristan Sinus, Motrin Childrens Cold)?

Ibuprofen is nonsteroidal anti-inflammatory drugs (NSAID) that reduces hormones that cause inflammation and pain in the body.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of ibuprofen and pseudoephedrine is used to treat stuffy nose, sinus congestion, cough, and pain or fever caused by the common cold or flu.

Ibuprofen and pseudoephedrine may also be used for purposes not listed in this medication guide.

What are the possible side effects of ibuprofen and pseudoephedrine (Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Children's Ibuprofen Cold Relief, Dristan Sinus, Motrin Childrens Cold)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medication and call your doctor at once if you have a serious side effect such as:

  • chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
  • bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • fast, pounding, or uneven heartbeat;
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
  • dangerously high blood pressure (severe headache, buzzing in your ears, confusion, chest pain, shortness of breath);
  • urinating less than usual or not at all;
  • skin rash, severe tingling, numbness, pain, muscle weakness; or
  • fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Less serious side effects may include:

  • upset stomach, nausea, heartburn, diarrhea, constipation;
  • bloating, gas, loss of appetite;
  • warmth, tingling, or redness under your skin;
  • dizziness, headache, feeling excited or restless;
  • sleep problems (insomnia); or
  • mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ibuprofen and pseudoephedrine (Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Children's Ibuprofen Cold Relief, Dristan Sinus, Motrin Childrens Cold)?

Do not use ibuprofen and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) within the past 14 days.

Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use this medication just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking ibuprofen, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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