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What should I discuss with my healthcare provider before taking imipramine (Tofranil, Tofranil-PM)?
You should not take this medicine if you have recently had a heart attack, or if you are allergic to imipramine or similar antidepressants such as amitriptyline, amoxapine, clomipramine, desipramine, doxepin, nortriptyline, protriptyline, or trimipramine.
Do not use imipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
To make sure imipramine is safe for you, tell your doctor if you have:
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using imipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.
FDA pregnancy category C. It is not known whether imipramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Imipramine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not give this medicine to a child without medical advice.
How should I take imipramine (Tofranil, Tofranil-PM)?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
If you need surgery, tell the surgeon ahead of time that you are using imipramine. You may need to stop using the medicine for a short time.
It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Do not stop using imipramine without first talking to your doctor. You may need to use less and less before you stop the medication completely.
Store at room temperature away from moisture and heat.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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