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What happens if I miss a dose (Tofranil, Tofranil-PM)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Tofranil, Tofranil-PM)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of imipramine can be fatal.
What should I avoid while taking imipramine (Tofranil, Tofranil-PM)?
Avoid drinking alcohol. It can cause dangerous side effects when taken together with imipramine.
Grapefruit and grapefruit juice may interact with imipramine. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.
Imipramine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid exposure to sunlight or tanning beds. Imipramine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
What other drugs will affect imipramine (Tofranil, Tofranil-PM)?
Taking imipramine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking imipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
You must wait at least 5 weeks after stopping fluoxetine (Prozac) before you can take imipramine.
Many drugs can interact with imipramine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with imipramine, especially:
This list is not complete and many other drugs can interact with imipramine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about imipramine.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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