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isoniazid and rifampin (cont.)

Who should not take isoniazid and rifampin (Rifamate)?

Before taking this medication, tell your doctor if you have

  • ever had an allergic reaction to isoniazid or rifampin;
  • disease;
  • liver disease; or
  • porphyria.

You may not be able to take isoniazid and rifampin, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether isoniazid and rifampin will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

It is also not known whether isoniazid and rifampin will harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take isoniazid and rifampin (Rifamate)?

Take isoniazid and rifampin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water.

Take isoniazid and rifampin on an empty stomach one hour before or two hours after meals.

If nausea occurs, ask your doctor if you can take isoniazid and rifampin with food.

Take all of the isoniazid and rifampin that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Your doctor may also want you to take a supplemental vitamin B6 (pyridoxine) tablet daily during treatment to prevent numbness and tingling caused by low levels of this vitamin.

Store this medication at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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