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What should I discuss with my healthcare provider before taking lansoprazole and naproxen (PREVACID NapraPAC 500)?

You should not use this medication if you are allergic to lansoprazole (Prevacid) or naproxen (Aleve, Anaprox, Naprosyn, and others), or if you have ever had a severe allergic reaction to aspirin or other NSAIDs.

Do not use lansoprazole and naproxen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

The naproxen in this medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

Naproxen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking lansoprazole and naproxen, especially in older adults.

To make sure you can safely take lansoprazole and naproxen, tell your doctor if you have any of these other conditions:

• liver or kidney disease;
• heart disease, high blood pressure, fluid retention, or a history of stroke, heart attack, or congestive heart failure;
• low levels of magnesium in your blood;
• a bleeding or blood clotting disorder, such as hemophilia;
• a history of stomach ulcers or bleeding;
• asthma, or a history of allergic reaction to aspirin, especially aspirin triad syndrome; or
• if you smoke.

FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking naproxen during the last 3 months of pregnancy may result in birth defects. Do not take lansoprazole and naproxen during pregnancy unless your doctor has told you to.

Naproxen can pass into breast milk and may harm a nursing baby. You should not breast-feed while taking lansoprazole and naproxen.

How should I take lansoprazole and naproxen (PREVACID NapraPAC 500)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Each package of this medication contains pills for 7 days of treatment (one lansoprazole capsule and two naproxen tablets per day). In most cases, you will take one lansoprazole (Prevacid) capsule and one naproxen (Naprosyn) tablet each morning before eating. The second naproxen tablet is then taken 12 hours later, without lansoprazole. Follow your doctor's instructions.

Do not crush, chew, break, or open the lansoprazole capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your kidney or liver function may also need to be tested. You may also need eye exams if you have any changes in your vision. Visit your doctor regularly.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using lansoprazole and naproxen.

Store at room temperature away from moisture, heat, and light.

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