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What should I discuss with my health care provider before taking lepirudin (Refludan)?
Do not use this medication if you are allergic to lepirudin, or to a similar medication called bivalirudin (Angiomax).
Before using lepirudin, tell your doctor if you are allergic to any drugs, or if you have:
If you have any of these conditions, you may not be able to use lepirudin, or you may need dosage adjustments or special tests during treatment.
It is not known whether lepirudin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take lepirudin (Refludan)?
Lepirudin is given as an injection through a needle placed into a vein. You will most likely receive this injection in a clinic or hospital setting.
Lepirudin must be given slowly through an IV infusion. This medication is usually given continuously for 2 to 10 days, or longer if needed.
To be sure this medication is helping your condition, your blood will need to be tested on a regular basis while you are receiving lepirudin.
Because lepirudin keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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