1. Take the Blood Disorders Quiz

What happens if I miss a dose (Refludan)?

Since lepirudin is usually given in a hospital or clinic setting as needed, it is not likely that you will miss a dose.

What happens if I overdose (Refludan)?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a lepirudin overdose may include severe bleeding.

What should I avoid while taking lepirudin (Refludan)?

Lepirudin lowers blood cells that help your blood clot. This can make it easier for you to bruise or bleed from an injury or minor cut. Avoid activities that increase your risk of a bruising or bleeding injury. Use extra caution to avoid cuts when brushing your teeth or shaving.

Avoid drinking alcohol while taking lepirudin. Alcohol may increase your risk of bleeding in your stomach or intestines.

What other drugs will affect lepirudin (Refludan)?

Before receiving lepirudin, tell your doctor if you are using or receiving any of the following drugs:

• a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); or
• any other medications used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

If you are using any of these drugs, you may not be able to use lepirudin, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect lepirudin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about lepirudin written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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