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maprotiline (cont.)

What should I discuss with my healthcare provider before taking maprotiline (Ludiomil)?

You should not take this medication if you are allergic to maprotiline, or if you have a seizure disorder.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Do not use maprotiline if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take maprotiline before the MAO inhibitor has cleared from your body.

Before taking maprotiline, tell your doctor if you are allergic to any drugs, or if you have:

  • liver or kidney disease;
  • if you are receiving electroshock therapy;
  • seizures or epilepsy;
  • a thyroid disorder;
  • heart disease, heart rhythm disorder;
  • a history of heart attack or stroke; or
  • a history of drug abuse or suicidal thoughts.

If you have any of these conditions, you may not be able to use maprotiline, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Maprotiline can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the side effects of this medication.

How should I take maprotiline (Ludiomil)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take the regular tablet form of maprotiline with water.

Maprotiline is usually taken once a day at bedtime. Follow your doctor's instructions.

It may take up to 3 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.

Store maprotiline at room temperature, away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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