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Brand Names: Menopur, Repronex

Generic Name: menotropins (injectable) (Pronunciation: MEN oh troe pins)

• What are menotropins (Menopur, Repronex)?
• What are the possible side effects of menotropins (Menopur, Repronex)?
• What is the most important information I should know about menotropins (Menopur, Repronex)?
• What should I discuss with my healthcare provider before using menotropins (Menopur, Repronex)?
• How should I use menotropins (Menopur, Repronex)?
• What happens if I miss a dose (Menopur, Repronex)?
• What happens if I overdose (Menopur, Repronex)?
• What should I avoid while using menotropins (Menopur, Repronex)?
• What other drugs will affect menotropins (Menopur, Repronex)?
• Where can I get more information?

What are menotropins (Menopur, Repronex)?

Menotropins are an equal mixture of the naturally occurring follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH are important for the development of follicles (eggs) produced by the ovaries and for the development of sperm.

Menotropins are used to stimulate ovulation (the release of an egg) when a woman's ovaries can produce a follicle but hormonal stimulation is deficient. Menotropins are also used to stimulate the development of multiple eggs for in vitro fertilization. Likewise, menotropins are used to stimulate the production of sperm in men who have functioning testes but in whom hormonal stimulation is deficient.

Menotropins may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of menotropins (Menopur, Repronex)?

Stop using menotropins and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Less than 2% of female patients treated with menotropins develop ovarian hyperstimulation syndrome (OHSS), especially after the first cycle of therapy. Symptoms of OHSS include swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, and nausea or vomiting. OHSS can be fatal. Notify your doctor immediately or seek emergency medical attention if you develop any of these side effects.

Serious pulmonary (lung and breathing) conditions have been reported in patients using menotropins. Seek medical attention if you experience any sudden changes in your breathing.

Other side effects may also occur. Notify your doctor if you experience

• ovarian enlargement presenting as abdominal or pelvic pain, tenderness, pressure, or swelling;
• nausea, vomiting, or diarrhea;
• shortness of breath;
• pain, warmth, or tenderness centralized in an arm or leg;
• fever or chills;
• headache or drowsiness;
• weakness or aching of muscles or joints;
• breast enlargement or tenderness;
• pain, swelling, or irritation at the injection site; or
• rash.

Menotropins may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about menotropins (Menopur, Repronex)?

Menotropins may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

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