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Medications and Drugs

Brand Names: Meprozine

Generic Name: meperidine and promethazine (Pronunciation: me PER i deen and pro METH a zeen)

What is meperidine and promethazine (Meprozine)?

Meperidine is a narcotic pain reliever.

Promethazine is an anti-nausea medication.

The meperidine and promethazine combination is used to treat moderate to severe pain.

Meperidine and promethazine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of meperidine and promethazine (Meprozine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using meperidine and promethazine and call your doctor at once if you have any of these serious side effects:

  • fast, slow, or uneven heartbeats;
  • shallow breathing;
  • extreme weakness or drowsiness;
  • feeling light-headed, fainting;
  • feeling anxious or agitated;
  • urinating less than usual;
  • tremors; or
  • unusual thoughts or behavior.

Less serious side effects may include:

  • constipation;
  • mild nausea or stomach upset;
  • warmth, tingling, or redness under your skin;
  • blurred vision; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about meperidine and promethazine (Meprozine)?

Before using meperidine and promethazine, tell your doctor if you have heart disease, kidney or liver disease, asthma or a sulfite allergy, a head injury or brain tumor, seizures, underactive thyroid, Addison's disease, glaucoma, urination or prostate problems, or a history of drug or alcohol abuse.

Do not take this medication if you have taken an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take meperidine and promethazine before the MAO inhibitor has cleared from your body.

Do not drink alcohol while you are taking meperidine and promethazine. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol.

Never take more than your prescribed dose of meperidine. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Meperidine and promethazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not stop using meperidine and promethazine suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Meperidine and promethazine may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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