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meperidine and promethazine (cont.)

What should I discuss with my health care provider before taking meperidine and promethazine (Meprozine)?

Do not use this medication if you have taken an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take meperidine and promethazine before the MAO inhibitor has cleared from your body.

Meperidine and promethazine may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Before using meperidine and promethazine, tell your doctor if you have:

  • heart disease or a heart rhythm disorder;
  • kidney disease;
  • liver disease;
  • underactive thyroid;
  • an allergy to sulfites;
  • asthma or a breathing disorder;
  • a history of head injury or brain tumor;
  • epilepsy or other seizure disorder;
  • glaucoma;
  • Addison's disease;
  • prostate enlargement or urination problems; or
  • a history of drug or alcohol dependence or abuse.

If you have any of these conditions, you may not be able to use meperidine and promethazine, or you may need a dosage adjustment or special tests during treatment.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Meperidine and promethazine may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take meperidine and promethazine (Meprozine)?

Take this medication exactly as it was prescribed for you. Never take meperidine and promethazine in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Take this medicine with a full glass of water.

Take meperidine with food or milk if it causes stomach upset.

Do not stop taking meperidine and promethazine suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Store meperidine and promethazine at room temperature away from moisture and heat.

After you have stopped using this medication, flush any unused pills down the toilet.

Keep track of how many pills have been used from each new bottle of this medicine. Meperidine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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