What happens if I miss a dose (Purinethol)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Purinethol)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
What should I avoid while taking mercaptopurine (Purinethol)?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while using mercaptopurine. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), oral polio, rotavirus, typhoid, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.
What other drugs will affect mercaptopurine (Purinethol)?
Tell your doctor about all other cancer treatments you are receiving. Also tell your doctor about all other medicines you use, especially:
- acetaminophen (Tylenol);
- allopurinol (Zyloprim, Aloprim, Lopurin);
- auranofin (Ridaura);
- azathioprine (Azasan, Imuran);
- cyclosporine (Gengraf, Neoral, Sandimmune);
- methotrexate (Rheumatrex, Trexall);
- olsalazine (Dipentum), mesalamine (Pentasa, Rowasa, Asacol), or sulfasalazine (Azulfidine);
- sulfamethoxazole and trimethoprim (Bactrim, Septra, Sulfatrim, SMX-TMP, and others);
- thioguanine (Tabloid);
- birth control pills or hormone replacement therapy;
- a blood thinner such as warfarin (Coumadin, Jantoven);
- tuberculosis medications;
- cholesterol medications such as niacin (Advicor, Niaspan, Niacor, Simcor, Slo Niacin, and others), atorvastatin (Lipitor, Caduet), simvastatin (Zocor, Simcor, Vytorin), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), and others;
- an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or
- an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
- an antibiotic such as dapsone, erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or rifampin (Rifater, Rifadin, Rifamate);
- antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);
- seizure medications such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), felbamate (Felbatol), valproic acid (Depakene); or
- HIV/AIDS medications such as abacavir/lamivudine/zidovudine (Trizivir), lamivudine (Combivir, Epivir), nevirapine (Viramune), tenofovir (Viread), or zidovudine (Retrovir);
This list is not complete and other drugs may interact with mercaptopurine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your doctor or pharmacist can provide more information about mercaptopurine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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