metformin and repaglinide (cont.)
What happens if I miss a dose (PrandiMet)?
Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (PrandiMet)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.A metformin and repaglinide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
Overdose may also cause a life-threatening condition called lactic acidosis. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
What should I avoid while taking metformin and repaglinide (PrandiMet)?
Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis while taking metformin and repaglinide.
What other drugs will affect metformin and repaglinide (PrandiMet)?
Using beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), and propranolol (Inderal, InnoPran) can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any heart or blood pressure medication.
Tell your doctor about all other medicines you use, especially:
- cimetidine (Tagamet) or ranitidine (Zantac);
- cyclosporine (Gengraf, Neoral, Sandimmune);
- delavirdine (Rescriptor);
- digoxin (digitalis, Lanoxin);
- fluconazole (Diflucan) or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
- morphine (MS Contin, Kadian, Oramorph);
- nicardipine (Cardene) or nifedipine (Nifedical, Procardia);
- procainamide (Procan, Procanbid, Pronestyl);
- quinidine (Quin-G) or quinine (Qualaquin);
- rifampin (Rifater, Rifadin, Rifamate);
- tolbutamide (Orinase);
- trimethoprim (Bactrim, Septra, Cotrim);
- vancomycin (Vancocin);
- ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
- a diuretic such as amiloride (Midamor), furosemide (Lasix), or triamterene (Dyrenium); or
- a non-steroidal anti-inflammatory drug (NSAID) such as flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), mefenamic acid (Ponstel), or piroxicam (Feldene).
This list is not complete and other drugs may interact with metformin and repaglinide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about metformin and repaglinide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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