metformin and rosiglitazone (cont.)
IN THIS ARTICLE
What should I discuss with my healthcare provider before taking metformin and rosiglitazone (Avandamet)?
Some people develop a life-threatening condition called lactic acidosis while taking metformin and rosiglitazone. You may be more likely to develop lactic acidosis if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk.
You should not use this medication if you are allergic to metformin (Glucophage) or rosiglitazone (Avandia), or if you have:
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and rosiglitazone.
To make sure you can safely take this medication, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver disease, or eye problems caused by diabetes.
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes.
FDA pregnancy category C. It is not known whether metformin and rosiglitazone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Some women using metformin and rosiglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.
Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking metformin and rosiglitazone. Talk with your doctor if you are concerned about this possibility.
It is not known whether metformin and rosiglitazone passes into breast milk or if it could harm a nursing baby. Do not take metformin and rosiglitazone without first talking to your doctor if you are breast-feeding a baby.
How should I take metformin and rosiglitazone (Avandamet)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Take metformin and rosiglitazone with meals, especially during the first few weeks of therapy.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating.
Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.
Your doctor may want you to stop taking metformin and rosiglitazone for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.
Ask your doctor how to adjust your dose if needed. Do not change your medication dose or schedule without your doctor's advice.
Your doctor may have you take extra vitamin B12 while you are taking metformin and rosiglitazone. Take only the amount of vitamin B12 that your doctor has prescribed.
Store at room temperature away from moisture and heat.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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