metformin and rosiglitazone (cont.)
What happens if I miss a dose (Avandamet)?
Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Avandamet)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking metformin and rosiglitazone (Avandamet)?
Avoid drinking alcohol. It can lower your blood sugar and may increase your risk of lactic acidosis while taking metformin and rosiglitazone.
What other drugs will affect metformin and rosiglitazone (Avandamet)?
Tell your doctor about all other medicines you use, especially:
- bosentan (Tracleer);
- delavirdine (Rescriptor);
- digoxin (Lanoxin);
- gemfibrozil (Lopid);
- morphine (MS Contin, Kadian, Oramorph);
- tolbutamide (Orinase);
- trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra);
- vancomycin (Vancocin, Lyphocin);
- amiloride (Midamor), furosemide (Lasix), or triamterene (Dyrenium);
- cimetidine (Tagamet) or ranitidine (Zantac);
- fluconazole (Diflucan) or ketoconazole (Nizoral);
- nicardipine (Cardene) or nifedipine (Nifedical, Procardia);
- procainamide (Procan, Pronestyl, Procanbid), quinidine (Quin-G), or quinine (Qualaquin);
- rifampin (Rifater, Rifadin, Rifamate) or rifapentine (Priftin);
- a non-steroidal anti-inflammatory drug (NSAID) such as flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), mefenamic acid (Ponstel), or piroxicam (Feldene); or
- seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), phenobarbital (Solfoton), primidone (Mysoline), and others.
You may be more likely to have hyperglycemia (high blood sugar) if you are taking metformin and rosiglitazone with other drugs that raise blood sugar, such as:
- diuretics (water pills);
- steroids (prednisone and others);
- heart or blood pressure medication (Cartia, Cardizem, Covera, Isoptin, Verelan, and others);
- niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
- phenothiazines (Compazine and others);
- thyroid medicine (Synthroid and others);
- birth control pills and other hormones;
- seizure medicines (Dilantin and others); and
- diet pills or medicines to treat asthma, colds or allergies.
These lists are not complete and there are many other medicines that can increase or decrease the effects of metformin and rosiglitazone on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about metformin and rosiglitazone.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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