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methotrexate (injection) (cont.)

IN THIS ARTICLE

What happens if I miss a dose (Methotrexate Sodium, Preservative Free)?

Call your doctor for instructions if you miss an appointment for your methotrexate injection.

What happens if I overdose (Methotrexate Sodium, Preservative Free)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methotrexate injection can be fatal.

Overdose symptoms may include headache, confusion, nausea, vomiting, or seizure (convulsions).

What should I avoid while receiving methotrexate injection (Methotrexate Sodium, Preservative Free)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid exposure to sunlight or artificial UV rays (sunlamps, tanning beds, or PUVA treatment), especially if you have psoriasis. Methotrexate injection can make your skin more sensitive to sunlight and your psoriasis may worsen.

What other drugs will affect methotrexate injection (Methotrexate Sodium, Preservative Free)?

Many drugs can interact with methotrexate injection. Below is just a partial list. Tell your doctor if you are using:

  • any other cancer medications, especially cisplatin (Platinol);
  • phenytoin (Dilantin);
  • diabetes medication you take by mouth;
  • retinol, tretinoin (Vesanoid, Retin-A), isotretinoin (Accutane, Amnesteem, Claravis, Sotret);
  • theophylline (Elixophyllin, Slo-Bid, Theobid, Theo-Dur);
  • vitamin or mineral supplements containing folic acid;
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
  • salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others;
  • sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others);
  • an antibiotic such as chloramphenicol (Chloromycetin), tetracycline, penicillin, ampicillin (Principen), amoxicillin (Amoxil, Trimox), or an antibiotic given by injection;
  • medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);
  • medicines used to prevent organ transplant rejection, such as azathioprine (Imuran), sirolimus (Rapamune) or tacrolimus (Prograf); or
  • antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir).

This list is not complete and there are many other drugs that can interact with methotrexate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your doctor or pharmacist can provide more information about methotrexate injection.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Revision date: 3/31/2011.

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