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methylene blue (oral and injection) (cont.)

What should I discuss with my health care provider before taking methylene blue (Urolene Blue)?

Do not use methylene blue if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

During your treatment with methylene blue, do not start or stop using any other medications unless your doctor tells you to.

Many drugs can interact with methylene blue. Tell your doctor about all other medications you use. You may need to stop using certain medicines before using methylene blue (in some cases for up to 5 weeks before you start methylene blue). However, do not stop taking any of your medications without your doctor's advice. This includes:

You should not use this medication if you are allergic to methylene blue, or if you have severe kidney problems.

To make sure you can safely use methylene blue, tell your doctor if you have any of these other conditions:

  • kidney disease; or
  • glucose-6-phosphate dehydrogenase (G6PD) deficiency.

FDA pregnancy category C. It is not known whether methylene blue will harm an unborn baby, but the medication may sometimes be used during pregnancy. Your doctor will determine whether or not this medication is safe or if it will harm the unborn baby. Before you are treated with methylene blue, tell your doctor if you are pregnant.

It is not known whether methylene blue passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take methylene blue (Urolene Blue)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

The usual dose of oral methylene blue is 1 or 2 tablets after meals, 3 times per day.

Take the methylene blue tablet after a meal, with a full glass (8 ounces) of water.

Methylene blue injection is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

To be sure this medication is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with methylene blue. Visit your doctor regularly.

Methylene blue will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using methylene blue.

Store methylene blue tablets at room temperature away from moisture, heat, and light.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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