Medications and Drugs

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Brand Names: Metozolv ODT, Reglan

Generic Name: metoclopramide (Pronunciation: MET oh KLOE pra mide)

• What is metoclopramide (Metozolv ODT, Reglan)?
• What are the possible side effects of metoclopramide (Metozolv ODT, Reglan)?
• What is the most important information I should know about metoclopramide (Metozolv ODT, Reglan)?
• What should I discuss with my healthcare provider before taking metoclopramide (Metozolv ODT, Reglan)?
• How should I take metoclopramide (Metozolv ODT, Reglan)?
• What happens if I miss a dose (Metozolv ODT, Reglan)?
• What happens if I overdose (Metozolv ODT, Reglan)?
• What should I avoid while taking metoclopramide (Metozolv ODT, Reglan)?
• What other drugs will affect metoclopramide (Metozolv ODT, Reglan)?
• Where can I get more information?

What is metoclopramide (Metozolv ODT, Reglan)?

Metoclopramide increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Metoclopramide is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.

Metoclopramide is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can cause nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.

Metoclopramide may also be used for other purposes not listed in this medication guide.

Metoclopramide 10 mg-APH

round, white, imprinted with INV 264

Metoclopramide 10 mg-BAR

round, white, imprinted with PLIVA 430

Metoclopramide 10 mg-TEV

round, white, imprinted with BL, 93

Metoclopramide 5 mg-BAR

round, green, imprinted with PLIVA 517

Metoclopramide 5 mg-TEV

round, white, imprinted with BL, 92

Metoclopramine 5 mg-APH

round, white, imprinted with INV 263

Reglan 10 mg

oblong, white, imprinted with REGLAN, AHR 10

What are the possible side effects of metoclopramide (Metozolv ODT, Reglan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using metoclopramide and call your doctor at once if you have any of these serious side effects:

• tremors, or restless muscle movements in your eyes, tongue, jaw, or neck;
• mask-like appearance of the face;
• very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
• depressed mood, thoughts of suicide or hurting yourself;
• hallucinations, anxiety, agitation, jittery feeling, trouble staying still;
• swelling, fluid retention;
• jaundice (yellowing of your skin or eyes); or
• seizure (convulsions).

Less serious side effects may include:

• feeling restless, drowsy, tired, or dizzy;
• headache, sleep problems (insomnia);
• nausea, vomiting, diarrhea;
• breast tenderness or swelling;
• changes in your menstrual periods; or
• urinating more than usual.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about metoclopramide (Metozolv ODT, Reglan)?

You should not take this medication if you are allergic to metoclopramide, or if you have bleeding or blockage in your stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).

Before taking metoclopramide, tell your doctor if you have kidney or liver disease, congestive heart failure, diabetes, or a history of depression.

Avoid drinking alcohol. It can increase some of the side effects of metoclopramide.

There are many other medicines that can interact with metoclopramide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Do not take it in larger amounts than recommended, or for longer than 3 months. High doses or long-term use of metoclopramide may cause tremors or other uncontrollable muscle movements, especially in older women.

Stop using metoclopramide and call your doctor at once if you have tremors or uncontrolled muscle movements, fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing, depressed mood, thoughts of suicide or hurting yourself, hallucinations, anxiety, agitation, seizure, or jaundice (yellowing of your skin or eyes).

After you stop taking metoclopramide, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.