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metoclopramide (cont.)

What should I discuss with my healthcare provider before taking metoclopramide (Metozolv ODT, Reglan)?

You should not take this medication if you are allergic to metoclopramide, or if you have:

  • bleeding or blockage in your stomach or intestines;
  • a perforation (hole) in your stomach or intestines;
  • epilepsy or other seizure disorder; or
  • an adrenal gland tumor (pheochromocytoma).

To make sure you can safely take metoclopramide, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease (especially cirrhosis);
  • congestive heart failure;
  • high blood pressure;
  • Parkinson's disease;
  • diabetes (your insulin dose may need adjusting); or
  • a history of depression.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Metoclopramide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Metoclopramide should not be given to a child.

How should I take metoclopramide (Metozolv ODT, Reglan)?

Take exactly as prescribed by your doctor. Metoclopramide is usually taken for only 4 to 12 weeks. Follow the directions on your prescription label.

Take metoclopramide 30 minutes before eating. Metoclopramide is usually taken before meals and at bedtime. Your doctor may want you to take the medication as needed only with meals that usually cause heartburn. Follow your doctor's instructions.

Measure the liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

To take metoclopramide orally disintegrating tablet (Metozolv):

  • Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. If the tablet breaks, throw it away and take out a new one.
  • Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
  • Swallow several times as the tablet dissolves. You do not need to drink liquid to help the tablet dissolve.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

After you stop taking metoclopramide, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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