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What happens if I miss a dose (ProAmatine)?

Take the missed dose as soon as you remember then wait the prescribed amount of time before taking another dose. Generally, doses should not be taken less than 3 hours apart. Follow your doctor's instructions. Do not take a double dose of this medication, unless otherwise directed by your doctor.

What happens if I overdose (ProAmatine)?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a midodrine overdose may include increased blood pressure (flushing, headache, pounding heartbeat, blurred vision), goosebumps, difficulty urination, a feeling of being cold, and loss of consciousness.

What should I avoid while taking midodrine (ProAmatine)?

Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least 3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.

Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.

What other drugs will affect midodrine (ProAmatine)?

Before taking midodrine, talk to your doctor if you are taking any other medicines especially any of the following:

• an alpha adrenergic blocker such as alfuzosin (Uroxatral), doxazosin (Cardura), guanadrel (Hylorel), prazosin (Minipress), or terazosin (Hytrin);
• flecainide (Tambocor);
• cimetidine (Tagamet, Tagamet HB) or ranitidine (Zantac, Zantac 75);
• digoxin (Lanoxin);
• metformin (Glucophage);
• fludrocortisone (Florinef);
• triamterene (Dyrenium, Dyazide, Maxzide);
• drugs that stimulate alpha-adrenergic receptors such as pseudoephedrine, phenylephrine, ephedrine, or dihydroergotamine;
• quinidine (Quinaglute, Quinidex, Quin-Release); or
• procainamide (Procan SR, Procanbid, Pronestyl).

You may not be able to take midodrine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, irregular heartbeat medicines, or antidepressants without first talking to your doctor.

Drugs other than those listed here may also interact with midodrine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

Your pharmacist has additional information about midodrine written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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