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What happens if I miss a dose (Embeda)?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

Morphine and naltrexone is not for use on an as-needed basis for pain.

What happens if I overdose (Embeda)?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of morphine and naltrexone can be fatal. Overdose symptoms may include extreme drowsiness or limp feeling, pinpoint or dilated pupils, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.

What should I avoid while using morphine and naltrexone (Embeda)?

Do not drink alcohol while you are taking this medication. Dangerous side effects or death can occur when alcohol is combined with morphine and naltrexone.

Morphine and naltrexone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What other drugs will affect morphine and naltrexone (Embeda)?

Before taking this medication, tell your doctor if you take other medications that can make you sleepy or slow your breathing. This includes cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety.

Also tell your doctor if you are using pentazocine (Talwin), nalbuphine (Nubain), butorphanol (Stadol), or buprenorphine (Buprenex, Subutex).

Tell your doctor about all other medications you use, especially:

• a diuretic (water pill);
• quinidine (Quinaglute, Quinidex, Quin-Release);
• atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
• a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva);
• ulcer or irritable bowel medication;
• bladder or urinary medications such as tolterodine (Detrol);
• an antibiotic such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
• an antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
• heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), or verapamil (Calan, Covera, Isoptin, Verelan);
• HIV or AIDS medication such as indinavir (Crixivan) or ritonavir (Kaletra, Norvir); or
• medicines used to prevent organ transplant rejection.

This list is not complete and there may be other drugs that can interact with morphine and naltrexone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about morphine and naltrexone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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