Medications and Drugs
Brand Names: Simcor
Generic Name: niacin and simvastatin (Pronunciation: NYE a sin and SIM va stat in)
What is niacin and simvastatin (Simcor)?
Niacin, also called nicotinic acid, is a B vitamin (vitamin B3). It occurs naturally in plants and animals, and is also added to many foods as a vitamin supplement. Niacin is also present in many multiple vitamins and nutritional supplements.
Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).
The combination of niacin and simvastatin is used to lower cholesterol and triglycerides (types of fat) in the blood.
Niacin and simvastatin may also be used for purposes not listed in this medication guide.
What are the possible side effects of niacin and simvastatin (Simcor)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking niacin and simvastatin and call your doctor at once if you have any of these serious side effects:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about niacin and simvastatin (Simcor)?
You should not take this medication if you are allergic to niacin (Niaspan, Niacor, and others) or simvastatin (Zocor, Vytorin), if you are pregnant or breast-feeding, or if you have liver disease, severe bleeding, or a stomach ulcer.
In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Never take niacin and simvastatin in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects.
There are many other drugs that should not be used together with niacin and simvastatin. Tell your doctor about all medications you use. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Simvastatin can harm an unborn baby or cause birth defects. Do not use niacin and simvastatin if you are pregnant.
Before taking niacin and simvastatin, tell your doctor if you have ever had liver or kidney disease, diabetes, gout, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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