What happens if I miss a dose (Orfadin)?

Take the missed dose as soon as you remember. If it is almost time for your next regularly scheduled dose, skip the missed dose and take your next dose as directed.. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Orfadin)?

Seek emergency medical attention if you think you have taken too much of this medicine.

Symptoms of a nitisinone overdose may include skin rash, jaundice (yellowing of the skin or eyes), unusual bleeding, or problems with your eyes or vision.

What should I avoid while taking nitisinone (Orfadin)?

Nitisinone is only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You will need to avoid or restrict foods that contain tyrosine or phenylalanine.

Some of the foods that contain tyrosine include cheese, milk, sour cream, beer, wine, distilled liquor, chicken, beef, liver, fish, processed meats (bologna, hot dogs, pepperoni, hard sausages), meat tenderizer, herring or other dried fish, avocados, bananas, carrots, potatoes, oatmeal, brown rice, soy sauce, spinach, tomatoes, bean curd, raisins, red plums, garbanzo beans, soy beans, and almonds.

Foods that contain phenylalanine include diet sodas, beef, poultry, pork, fish, milk, yougurt, eggs, cheese, soybeans, soy protein, tofu, and certain nuts or seeds.

A major source of phenylalanine is the artificial sweetener aspartame (NutraSweet), which is contained in many diet or sugar-free drinks and food products. Before consuming any packaged food or beverage, carefully read the nutrition label to be sure the product does not contain phenylalanine or have a warning about phenylketonuria.

There are other foods that may contain tyrosine or phenylalanine. Be sure you are familiar with the list of foods you must avoid or restrict to help control your condition.

What other drugs will affect nitisinone (Orfadin)?

There may be other drugs that can affect nitisinone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has additional information about nitisinone written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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