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Medications and Drugs

Brand Names: Zofran, Zofran ODT, Zuplenz

Generic Name: ondansetron (oral) (Pronunciation: on DAN se tron)

What is ondansetron (Zofran, Zofran ODT, Zuplenz)?

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).

Ondansetron may be used for purposes not listed in this medication guide.

Ondansetron 4 mg ODT-MYL

round, white, imprinted with M, 732

Ondansetron 4 mg ODT-TEV

round, white, imprinted with 93, 7301

Ondansetron 4 mg-MYL

round, white, imprinted with M, 315

Ondansetron 4 mg-TEV

round, white, imprinted with 93, 233

Ondansetron 8 mg ODT-MYL

round, white, imprinted with M, 734

Ondansetron 8 mg ODT-TEV

round, white, imprinted with 93, 7302

Ondansetron 8 mg-MYL

round, orange, imprinted with M, 344

Ondansetron 8 mg-TEV

round, yellow, imprinted with 93, 7236

Zofran 4 mg

oval, white, imprinted with Zofran, 4

Zofran 8 mg

oval, yellow, imprinted with Zofran, 8

What are the possible side effects of ondansetron (Zofran, Zofran ODT, Zuplenz)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • blurred vision or temporary vision loss (lasting from only a few minutes to several hours);
  • severe dizziness, feeling short of breath, fainting, fast or pounding heartbeats;
  • slow heart rate, trouble breathing;
  • anxiety, agitation, shivering;
  • feeling like you might pass out; or
  • urinating less than usual or not at all.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ondansetron (Zofran, Zofran ODT, Zuplenz)?

You should not use this medication if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Do not take ondansetron if you are also using apomorphine (Apokyn).

Before taking ondansetron, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.

Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

The serious side effects of this medication include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking ondansetron and call your doctor at once if you have any of these side effects.

Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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