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Medications and Drugs

Brand Names: Zofran

Generic Name: ondansetron (injection) (Pronunciation: on DAN se tron)

What is ondansetron injection (Zofran)?

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron injection is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy).

Ondansetron injection may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of ondansetron injection (Zofran)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • blurred vision or temporary blindness;
  • muscle spasm or twitching, especially in your face; or
  • stiffness in your neck.

Other less serious side effects are more likely to occur, such as:

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ondansetron injection (Zofran)?

Before receiving ondansetron injection, tell your doctor if you have liver disease, a personal or family history of Long QT syndrome, or if you have had an allergic reaction to any medicine similar to ondansetron, including dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by ondansetron injection.

Ondansetron injection can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Call your doctor at once if you have stiffness in your neck, or muscle spasms or twitching (especially in your face).

There may be other drugs that can affect ondansetron injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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