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ondansetron (injection) (cont.)

What should I discuss with my healthcare provider before taking ondansetron (Zofran)?

You should not use ondansetron if you are allergic to it, or if you are also using apomorphine (Apokyn).

Ondansetron can cause serious heart rhythm problems. You should not use this medication if you have a history of Long QT syndrome. Tell your doctor if anyone in your family has ever had this condition.

To make sure ondansetron is safe for you, tell your doctor if you have:

  • liver disease;
  • a serious heart condition or heart rhythm disorder;
  • slow or fast heartbeats, or heart block;
  • congestive heart failure;
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
  • if you are allergic to medicines similar to ondansetron, such dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take ondansetron (Zofran)?

Ondansetron is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Ondansetron is usually given just before your surgery begins, or within 2 hours after surgery.

To prevent nausea and vomiting caused by chemotherapy, ondansetron is given 30 minutes before the start of chemotherapy. A second and third dose of ondansetron are sometimes given 4 hours and 8 hours after the first dose.

Ondansetron injection is not for preventing nausea or vomiting that is caused by factors other than chemotherapy or surgery.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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