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ondansetron (injection) (cont.)

What should I discuss with my health care provider before using ondansetron injection (Zofran)?

Before using ondansetron injection, tell your doctor if you have:

  • liver disease;
  • a history of allergic reaction to any medicine similar to ondansetron, including dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi); or
  • a personal or family history of Long QT syndrome.

If you have any of these conditions, you may not be able to use ondansetron injection, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Ondansetron can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is ondansetron injection used (Zofran)?

Ondansetron injection is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. In most cases, only one dose of ondansetron injection is given just before the start of surgery or chemotherapy. Sometimes a second and third dose are also given at 4 hours and 8 hours after the first dose. The medicine must be given through an IV infusion, and can take up to 15 minutes to complete.

Ondansetron injection is not for preventing nausea or vomiting that are caused by factors other than chemotherapy or surgery.

If you receive this medicine at home and you keep your medicine there, store ondansetron injection at room temperature away from heat and light.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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