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Medications and Drugs

Brand Names: Votrient

Generic Name: pazopanib (Pronunciation: paz OH pa nib)

What is pazopanib (Votrient)?

Pazopanib is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.

Pazopanib is used to treat advanced renal cell carcinoma (kidney cancer).

Pazopanib is also used to treat soft tissue sarcoma (a tumor that can develop in or around muscles, tendons, joints, organs, or blood vessels). Pazopanib is usually given after other cancer medications have been tried without successful treatment of soft tissue sarcoma.

Pazopanib may also be used for purposes not listed in this medication guide.

What are the possible side effects of pazopanib (Votrient)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using pazopanib and call your doctor at once if you have a serious side effect such as:

  • slow healing of a wound or surgical incision;
  • dizziness, fainting, fast or pounding heartbeat;
  • fever, chills, easy bruising, flu symptoms, sores in your mouth and throat;
  • feeling short of breath (even with mild exertion), swelling, rapid weight gain;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • nosebleed, bleeding gums;
  • any wound that will not heal;
  • nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, confusion, problems with vision, speech, or balance;
  • seizures (convulsions);
  • sudden cough, wheezing, rapid breathing, coughing up blood;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • pain, swelling, warmth, or redness in one or both legs; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • mild nausea or vomiting, diarrhea;
  • weight loss;
  • changes in hair or skin color;
  • joint or muscle pain;
  • tumor pain, mild headache; or
  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pazopanib (Votrient)?

Do not use pazopanib if you are pregnant. It could harm the unborn baby.

Before you take pazopanib, tell your doctor if you have liver disease, heart disease, high blood pressure, underactive thyroid, an ulcer or other stomach disorder, or a history of Long QT syndrome, blood clot, or bleeding (stomach, intestinal, or brain).

There are many other drugs that can interact with pazopanib. Tell your doctor about all medications you use.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using pazopanib. You may need to stop using the medicine for a short time.

Stop using pazopanib and call your doctor at once if you have a serious side effect such as bloody or tarry stools, coughing up blood, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes), sudden numbness or weakness, problems with speech or balance, chest pain, or vision and hearing problems.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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