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pazopanib (cont.)

What should I discuss with my health care provider before taking pazopanib (Votrient)?

You should not use this medication if you are allergic to it, or if you have severe liver disease.

To make sure you can safely take pazopanib, tell your doctor if you have any of these other conditions:

  • liver disease;
  • heart disease, heart rhythm disorder;
  • high blood pressure;
  • a personal or family history of Long QT syndrome;
  • a history of blood clot or stroke;
  • a thyroid disorder;
  • an ulcer or other stomach disorder;
  • headaches, seizures, or vision problems;
  • a head injury or bleeding in your brain within the past 6 months;
  • stomach or intestinal bleeding within the past 6 months; or
  • if you have had surgery within the past 7 days.

FDA pregnancy category D. Do not use pazopanib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether pazopanib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pazopanib.

How should I take pazopanib (Votrient)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take pazopanib on an empty stomach, at least 1 hour before or 2 hours after a meal.

Pazopanib is usually taken once per day. Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush a pazopanib tablet. Swallow the pill whole. Crushing the pill may cause your body to absorb too much of the drug at one time.

To be sure this medication is not causing harmful effects, your blood pressure will need to be checked often, and you may need blood or urine tests. Your heart rate may also need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using pazopanib. You will need to stop using the medicine at least 7 days before your surgery.

Store at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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