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pazopanib (cont.)

What should I discuss with my health care provider before taking pazopanib (Votrient)?

You should not use this medication if you are allergic to it.

To make sure you can safely take pazopanib, tell your doctor if you have any of these other conditions:

  • liver disease;
  • heart disease;
  • high blood pressure;
  • a personal or family history of "Long QT syndrome";
  • a history of blood clot;
  • underactive thyroid;
  • an ulcer or other stomach disorder;
  • a head injury or bleeding in your brain within the past 6 months; or
  • stomach or intestinal bleeding within the past 6 months.

FDA pregnancy category D. Do not use pazopanib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether pazopanib passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take pazopanib (Votrient)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take pazopanib on an empty stomach, at least 1 hour before or 2 hours after a meal.

Pazopanib is usually taken once per day. Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush a pazopanib tablet. Swallow the pill whole. Crushing the pill may cause your body to absorb too much of the drug at one time. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water and rinse thoroughly.

To be sure this medication is not causing harmful effects, your blood and urine may need to be tested often. Your heart rate may also need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using pazopanib. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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