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Medications and Drugs

Brand Names: Krystexxa

Generic Name: pegloticase (Pronunciation: peg LOE ti kase)

What is pegloticase (Krystexxa)?

Pegloticase is an enzyme that metabolizes uric acid into a harmless chemical that is eliminated from the body in urine.

Pegloticase is used to treat chronic gout. Pegloticase is usually given after other gout medications have been tried without successful treatment of symptoms.

Pegloticase may also be used for purposes not listed in this medication guide.

What are the possible side effects of pegloticase (Krystexxa)?

Some people receiving a pegloticase injection have had a reaction to the infusion (when the medicine is injected into the vein). Infusion reactions may also occur after the injection is given. Tell your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a fast heartbeat, chest discomfort, or redness of your skin during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain; or
  • flushing (warmth, redness, or tingly feeling).

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pegloticase (Krystexxa)?

You should not receive pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Some drugs can interact with pegloticase and should not be used at the same time, especially allopurinol (Zyloprim), probenecid (Benemid), or febuxostat (Uloric).

To make sure pegloticase is safe for you, tell your doctor if you have gout, congestive heart failure, other heart problems, or high blood pressure.

You may be given other medications to prevent certain side effects of pegloticase. You may need to start taking these medications at least a week before you receive your pegloticase injection. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Tell your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a fast heartbeat, chest discomfort, or redness of your skin when the medicine is injected into your vein.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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