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What happens if I miss a dose (Cuprimine, Depen)?

Take the missed dose on an empty stomach as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor. If you have missed several doses in a row, do not take any more doses without first talking to your doctor.

What happens if I overdose (Cuprimine, Depen)?

Seek emergency medical attention.

Symptoms of a penicillamine overdose are not known.

What should I avoid while taking penicillamine (Cuprimine, Depen)?

Follow any special diet restrictions recommended by your doctor.

What other drugs will affect penicillamine (Cuprimine, Depen)?

Do not take penicillamine if you are taking any of the following medicines:

• a gold-therapy product such as auranofin (Ridaura), aurothioglucose (Solganal), or gold sodium thiomalate (Myochrysine, Aurolate);
• an antimalarial medicine such as quinine (Quinamm), mefloquine (Lariam), chloroquine (Aralen), hydroxychloroquine (Plaquenil), primaquine, or pyrimethamine (Daraprim);
• a cancer chemotherapy medicine; or
• phenylbutazone.

Like penicillamine, the medications listed above can affect the blood and the kidneys. Combined with penicillamine, any of these medicines can be very dangerous.

Before taking penicillamine, tell your doctor if you are taking digoxin (Lanoxin, Lanoxicaps). Penicillamine may decrease the effects of digoxin, and your doctor may want to adjust your dosage or monitor your therapy.

Many other drugs, especially antacids and vitamin and mineral supplements, can decrease the effects of penicillamine. Do not take any medicines or over-the-counter drugs or supplements within 1 hour of a penicillamine dose.

Drugs other than those listed here may also interact with penicillamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about penicillamine written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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