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Medications and Drugs

Brand Names:

Generic Name: penicillin G sodium (Pronunciation: PEN i SIL in G SOE dee um)

What is penicillin G sodium ()?

Penicillin G sodium is a fast-acting antibiotic that fights bacteria in your body.

Penicillin G sodium is used to treat many different types of severe infections, including strep infections, meningitis, anthrax, pneumonia, gonorrhea, and syphilis.

Penicillin G sodium may also be used for purposes not listed in this medication guide.

What are the possible side effects of penicillin G sodium ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • blood in your urine;
  • feeling like you might pass out;
  • fever, chills, swollen glands, body aches, flu symptoms, rash or itching, muscle or joint pain, night sweats, general ill feeling;
  • white patches or sores inside your mouth or on your lips;
  • urinating less than usual or not at all;
  • skin rash with bruising, severe tingling, numbness, pain, muscle weakness;
  • swelling in your hands or feet;
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • twitching or uncontrollable muscle movements; or
  • increased thirst, feeling restless, increased urination, muscle pain or weakness, irregular heart rate, weak pulse, tingly feeling, feeling light-headed, fainting, or seizure (convulsions).

Less serious side effects may include:

  • pain, swelling, bruising, or irritation around the IV needle;
  • overactive reflexes;
  • nausea, vomiting; or
  • black or hairy tongue.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about penicillin G sodium ()?

You should not use this medication if you are allergic to penicillin. Tell your doctor if you have ever had an allergic reaction to a cephalosporin antibiotic such as Ceftin, Cefzil, Omnicef, Keflex, and others.

Before using penicillin G sodium, tell your doctor if you have asthma or a history of allergies, liver disease, kidney disease, or heart disease.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Penicillin G sodium will not treat a viral infection such as the common cold or flu.

After you have finished your treatment with penicillin G sodium, your doctor may want to do tests to make sure your infection has completely cleared up.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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