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Medications and Drugs

Brand Names: Trental

Generic Name: pentoxifylline (Pronunciation: pen tox I fi leen)

What is pentoxifylline (Trental)?

Pentoxifylline causes changes in your blood that help improve blood flow. This also helps your blood carry oxygen to your tissues and organs.

Pentoxifylline is used to improve blood flow and reduce certain symptoms of a condition called intermittent claudication (IN-ter-MIT-ent KLOD-ih-KAY-tion). Pentoxifylline is not a cure for this condition.

Pentoxifylline may also be used for purposes not listed in this medication guide.

Pentoxifylline 400 mg-APO

oval, white, imprinted with APO 033

Pentoxifylline 400 mg-ESI

oblong, white, imprinted with P77, 511

Pentoxifylline 400 mg-MYL

oblong, lavender, imprinted with MYLAN, 357

Pentoxifylline 400 mg-TEV

oblong, white, imprinted with BVF, 0117

Trental 400 mg

oblong, pink, imprinted with HOECHST, TRENTAL

What are the possible side effects of pentoxifylline (Trental)?

Stop taking this medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain,
  • pounding heartbeats or fluttering in your chest;
  • feeling like you might pass out;
  • red or pink urine;
  • bloody, black, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • dizziness, headache;
  • blurred vision;
  • flushing (warmth, redness, or tingly feeling);
  • gas, bloating, upset stomach; or
  • nausea, vomiting, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pentoxifylline (Trental)?

You should not use this medication if you are allergic to pentoxifylline, or if you are allergic to caffeine or theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others).

You also should not use pentoxifylline if you are breast-feeding a baby, or if you have recently had any type of bleeding in your brain or the retina of your eye.

Before you take pentoxifylline, tell your doctor if you have angina (chest pain), a heart rhythm disorder, high blood pressure, a stomach or intestinal ulcer, kidney disease, or if you have recently had surgery.

Tell your doctor about all other medicines you use, especially warfarin (Coumadin, Jantoven), theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others), or blood pressure medication.

Take pentoxifylline with food.

Stop taking this medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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