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February 10, 2012
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Medications and Drugs

Brand Names: Permax

Generic Name: pergolide (Pronunciation: PER go lide)

What is pergolide (Permax)?

Pergolide was withdrawn from the U.S. market on March 29, 2007.

Pergolide is used to treat Parkinson's disease. Parkinson's disease is associated with low levels of a chemical called dopamine (DOE pa meen) in the brain. Pergolide has some of the same effects as dopamine in the body.

Pergolide is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Pergolide is often used in conjunction with other medicines in the treatment of Parkinson's disease.

Pergolide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of pergolide (Permax)?

Stop taking pergolide and seek emergency medical attention or contact your doctor immediately if you experience any of the following serious side effects:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • irregular heartbeats;
  • hallucinations (seeing or hearing things that are not real), confusion, or altered consciousness; or
  • dizziness (especially when rising from a sitting or lying position).

Other, less serious side effects may be more likely to occur. Continue to take pergolide and talk to your doctor if you experience

  • mild nausea, vomiting, upset stomach, or decreased appetite;
  • diarrhea or constipation;
  • dry mouth;
  • drowsiness;
  • insomnia; or
  • agitation or anxiety.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about pergolide (Permax)?

Pergolide was withdrawn from the U.S. market on March 29, 2007.

Use caution when driving, operating machinery, or performing other hazardous activities. Pergolide may cause drowsiness or low blood pressure (leading to dizziness and other symptoms), especially when rising from a sitting or lying position. Rise slowly and use caution when performing hazardous activities until you know how this medication affects you.

Do not stop taking pergolide without first talking to your doctor. Stopping pergolide suddenly may cause potentially dangerous side effects such as elevated body temperature, muscle rigidity, confusion or altered consciousness, and other problems.


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Muscle Strain »

Muscle Strain Overview

Muscle strain is injury to muscle as a result of strenuous activity. Almost anyone can put undue pressure on muscles during the course of normal daily activities, with sudden, quick heavy lifting, during sports, or while performing work tasks. Muscle strain is sometimes referred to as muscle pull. A severe muscle strain can result in a muscle tear. The tearing of the muscle can also damage small blood vessels, causing local bleeding (bruising) and pain (caused by irritation of the nerve endings in the area). A sprain, in contrast, is an injury to ligaments.

Muscle Strain Symptoms and Signs

  • Swelling, bruising or redness, or open cuts as a consequence of the injury
  • Pain at rest
  • Pain when the specific muscle or the joint in relation to that muscle is used
  • Weakness of the muscle or tendons (A sprain, in contrast, is an injury to a joint and its ligaments.)
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Read the Muscle Strain article »


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